As an alternative to maintaining multiple Toolbx containers for each command-line tool, you can use one Toolbx and install and manage your packages with Nix. This approach keeps your tools off the Fedora Silverblue host while letting Nix handle package installation and updates in a single Toolbx container.

According to the manual:

The command nix-shell will build the dependencies of the specified derivation, but not the derivation itself. It will then start an interactive shell in which all environment variables defined by the derivation path have been set to their corresponding values, and the script $stdenv/setup has been sourced. This is useful for reproducing the environment of a derivation for development.

How does that help me?